ResourceSeparations
Peptide Cleavage and Protected Cleavage Procedures
4 Dec 2018In Fmoc synthesis, the removal of the peptide from the solid support is typically accomplished with trifluoroacetic acid (TFA). Because the side chain protecting groups used in Fmoc synthesisare acid labile, a single step both cleaves the peptide from the resin and removes the protecting groups. Various scavenger molecules are added to the TFA to prevent the cleaved protecting groups from reattaching to the peptide. The particular scavengers used depend on the specific peptide sequence.
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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.PeptidesPeptides are short chains of amino acids that play key roles in biological processes, including signaling, immune responses, and enzyme regulation. Peptide research is critical in drug discovery, diagnostics, and vaccine development. Browse our peer-reviewed product directory to find the best peptides and peptide-related products, compare options, check reviews, and get pricing directly from manufacturers.Peptide Chemistry