ResourceSpectroscopy
Overcoming Optical Focus Issues in Handheld Raman Systems for Analysis of Pharmaceutical Drug Formulations
20 Mar 2015This application note describes the advantages of using the optical focus technique – the Orbital-Raster-Scan (ORS) – in Metrohm’s handheld Raman system “Mira” over traditional techniques. The experiments demonstrated the benefits of using ORS technique to perform identification and quantification of drug formulations. The reproducibility of Raman signals from target active pharmaceutical ingredients (APIs) in the effervescent cold medicine was increased, the analysis time was faster and the matching power of known drug formulations to library spectra was improved and more consistent.
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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.FormulationFormulation is the process of combining active pharmaceutical ingredients with excipients to produce a drug which is both stable and active.