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Osmolality as a Concentration Measurement Method for Key Buffers in Bioprocessing
28 Oct 2019The manufacturing of biologics is a complex and costly process by which a protein is recovered and purified of contaminants to ultimately generate a drug product. This is accomplished through a chain of filtration and chromatography processes. Achieving and maintaining the desired product quality and purity requires optimization of process parameters as well as precise control of these parameters.
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Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.OsmometryIn osmometry, the osmotic strength of a solution, colloid or compound is measured. Osmotic strength is a measurement of the total concentration (distinct from molarity) of dissolved material in solution. This technique is often used for the determination of average molecular weight.BiologicsBiologics are medical products derived from living organisms, including vaccines, gene therapies, and monoclonal antibodies. These treatments are key to modern healthcare, especially in oncology and autoimmune diseases. Explore biologics research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.ManufacturingManufacturing is the production of merchandise for use or sale using labor and machines, tools, chemical and biological processing, or formulation.