Optimising PFAS reference material design for use with LC–HRAM

25 Mar 2025

PFAS have been detected globally, and in various environmental matrices that indicate widespread exposure – including water, soil, and air, as well as human blood samples. Exposure to PFAS has also been associated with a range of adverse health effects: epidemiological studies linking it to liver damage, thyroid disease, decreased fertility, increased cholesterol levels, and a higher risk of certain cancers.

Explore strategies for monitoring PFAS and the importance of understanding the factors that can cause bias in reference materials used for PFAS analysis, so that results are as accurate as possible.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PFAS
Optimizing PFAS reference material design for LC - high resolution accurate MS