ResourceLife Sciences
Non-Invasive Analysis of Drug Sensitivity in Homo and Heterotypic Multicellular Tumor Spheroids
5 Feb 2015To gain full benefit of more organotypic tumor culture systems, appropriate assays which enable high-throughput analysis over time without disrupting the tissues have to be adopted. Read outs for co-culture systems which allow the discrimination of a drug effect on the cancer cell and stroma environment will be a tremendous improvement when using complex 3D models. This poster reports the development of microtissue models harboring fluorescence reporter for non-disruptive drug sensitivity testing of homotypic and heterotypic colon cancer spheroids.
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SpheroidsSpheroids are clusters of cells that have been grown in 3D culture to be used as <i>in vitro</i> model systems. These 3D microtissues can be used for toxicology testing, DMPK studies and many other applications involving cell analysis.Colorectal Cancer