No-D NMR: A method for obtaining NMR spectra without the need for deuterated solvents

For the majority of nuclear magnetic resonance (NMR) spectroscopy users today, sample preparation follows a similar path: isolate a compound or compounds from a reaction mixture (or, if fortunate, a pure product), dissolve it in an appropriate deuterated solvent, mix well, fill a quality NMR tube to the minimum required height, place the sample in a sample changer, and submit the sample for the requested analysis. In most modern spectrometers, tasks such as locking, shimming, and tuning happen automatically before data acquisition. With these conditions met and appropriate experimental parameters chosen, the chemist stands a good chance of receiving useful information about their sample.