ResourceSpectroscopy
Near-Infrared-Labeled Tetracycline Derivative is an Effective Marker of Bone Deposition in Mice
11 Sept 2011Bone-specific compounds have been used for the detection of bone mineralization, growth, and morphological changes in this application note. A subset of iminodiacetic acid chelators were exploited to produce a near
infrared (NIR) optical bone marker for preclinical animal imaging. By conjugating target compounds to
IRDye® 800CW, the effective fluorescence signal detection to the NIR region was extended without affecting the
compound’s ability to function as a marker.
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IRDye 800CW Infrared Dyes
LICORbioImaging probes conjugated to IRDye 800CW and IRDye 700DX have propelled more than 20 Phase I and Phase II clinical trials worldwide.
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Near Infrared SpectroscopyNear-infrared (NIR) spectroscopy measures the interaction of near-infrared light with a sample, including transmission, reflectance and absorbance, facilitating the identification of analytes. Measurements can be conducted using a Fourier-transform near infrared (FT-NIR) spectrometer, while there are also UV-Vis- NIR spectrophotometers that measure a broader spectrum of wavelengths. Find the best NIR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.