ResourceLife Sciences
Multisizer 4 Coulter Counter: Optimized Procedures for Running Protein Samples
10 Mar 2015Beckman Coulter’s Multisizer 4 provides analysts with an easy-to-use, technologically-advanced system that can solve most particle sizing and counting challenges. Although the procedures described in this application note address common issues encountered when analyzing subvisible particles in protein formulations, the general guidelines can also be used for applications requiring small aperture tubes.
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Multisizer 4e Coulter Counter
Beckman Coulter DiagnosticsThe Multisizer 4e, the latest COULTER COUNTER designed with the SMART and DPP technologies, offers highly accurate and reliable particle counting and sizing. Discover the most versatile and accurate particle sizing and counting analyzer on the market.
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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein ExpressionProtein expression is the utilization of cell machinery for the synthesis of proteins and has become a critical tool in biotherapeutic, genomic, and proteomic research. Produce recombinant proteins with expression vectors in combination with a host cell suitable for high-level protein expression. For production of toxic proteins, consider cell-free expression vectors. Create and monitor post-translational modifications with protein modification kits. Find the best protein expression products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.