ResourceSpectroscopy
Molecular Imaging of Animal and Human Tissue Samples by LAESI-MS
18 Jan 2013This application note discusses Laser Ablation Electrospray Ionization (LAESI) an ambient ionization technique that generates ions from tissue samples that are then introduced and detected by a mass spectrophotometer. Focusing specifically on the uses of the Protea LAESI® DP-1000 Direct Ionization System for mass spectrometry imaging of various samples including mouse body sections and skin tissues samples. This system provides the ability to map the location of biomolecules, such as lipids and small molecules in tissues without the need to add a matrix to a sample.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.ImagingImaging techniques are essential for obtaining visual representations of samples to understand structures, processes, and function in biological, chemical, and physical research. These tools range from traditional light microscopy to advanced imaging modalities like MRI and electron microscopy, providing researchers with valuable data for diagnostics, drug discovery, and material analysis. Explore imaging solutions in our peer-reviewed product directory to compare products, check reviews, and get pricing directly from manufacturers.Laser AblationImaging Mass Spectrometry