Micropatterned Primary Hepatocyte Co-Cultures for Drug Metabolism and Toxicity Studies

19 Aug 2014

This application note describes a human liver model, HepatoPac, with precise microscale cyto-architecture and optimal stromal interactions (micropatterned co-cultures) that displays stable functions for several weeks in vitro.

Human HepatoPac™ Kits

Hepregen Corporation

Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).HepatoPac™ kits can be used for any assay that can be run using sandwich, monoculture plates or suspension cultures. Due to the extended in vitro functionality of HepatoPac™ co-cultures, Hepregen kits enable studies such as low turnover clearance or chronic toxicity studies that could not otherwise be performed.Human HepatoPac™ Kits Features: HT-ready format; 24- and 96-well plates Proprietary micropatterened co-culture Superior data for both slowly and rapidly metabolized drugs Culture longevity of up to 4 weeks Kits contain: Human HepatoPac™ Co-Cultures Maintenance Media Application-specific Media and additives Instructions for culture maintenance and application-specific protocols On-site customer training included

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.HepatocytesIn Vitro DiagnosticsIn vitro diagnostics (IVD) involve testing samples outside the body, typically in a laboratory, to diagnose diseases or conditions. IVD technologies include blood tests, molecular assays, and other bodily fluid tests, enabling accurate diagnosis and monitoring of diseases. These tests are essential for guiding treatment decisions in clinical settings. Browse our peer-reviewed product directory to find the best IVD solutions; compare products, check reviews, and get pricing directly from manufacturers.
Micropatterned Primary Hepatocyte Co-Cultures for Drug Metabolism and Toxicity Studies