ResourceLife Sciences
Microchip CE-MS: A powerful tool for biotherapeutic characterization
30 Jun 2025This eBook explores the power of the ZipChip microchip capillary electrophoresis–mass spectrometry (CE-MS) platform in simplifying charge variant analysis and accelerating biologic drug characterization. Featuring high-throughput, plug-and-play capabilities, ZipChip offers faster data acquisition and enhanced separation for therapeutic development.
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ZipChip™
Repligen CorpZipChip enables seamless CE/ESI-MS workflow and provides fast CE separation, nano-spray level sensitivity to obtain high-resolution separation and mass spec data from characterization of intact proteins, antibody drug conjugates (ADCs), antibody subunits, peptides, and nucleic acids.
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Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.