ResourceSpectroscopy
Method Development Considerations for Paper Spray Mass Spectrometry - Direct Ionization Technique for Physiological Fluid Analysis
5 Jun 2016Sports doping in both humans and animals is a widespread problem. Paper spray is a direct ionization technique that simplifies the mass spectrometric analysis of compounds from physiological fluids, making it an attractive method for clinical research and forensic toxicology applications. In this work, methamphetamine and other stimulant drugs were spiked in horse urine to demonstrate the potential of the technique to monitor sport doping in horse racing. Paper spray ionization presents challenges for mass spectrometric analysis due to the lack of specimen matrix clean-up and lack of chromatography. This poster outlines a method development approach using paper spray Ionization mass spectrometry with this in mind.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Equine UrineEquine DopingClinical Mass SpectrometryMass spectrometry is emerging as a superior method of analysis over the longstanding, gold standard of immunoassay. Clinical mass spectrometry systems are increasingly accessible to medical laboratories and are capable of providing results with more speed and less expense than traditional methods. From simple mass spectrometers to IVDR class A compliant, highly sophisticated systems performing liquid chromatography tandem mass spectrometry (LC/MS/MS), find the latest product news, reviews and resources to make a purchasing decision for your laboratory. Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.Human UrineHuman urine can be used in a number of tests for human health diagnosis, treatment assessments and the detection drug use. Techniques used with Human urine include LC-MS/MS, SLE, GC-MS, SPE and mass spectrometry.UrineThe analysis of urine is important in medicinal, anti-doping, forensic and life sciences applications. The ability to evaluate what someone has ingested through their urine enables fast detection and diagnosis of certain illnesses.