ResourceSpectroscopy
Metabolic Characterization of Tumor-Tumor Microenvironment Interactions in Human Colorectal Cancer using MALDI Mass Spectrometry Imaging
2 Sept 2013This poster highlights a novel use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to characterize the metabolic interplay between colorectal cancer epithelium and adjacent stroma. The advancing cancer margin/edge harbors unique biological features, and characterizing tumor-tumor microenvironment coupling at this ‘front-line’ zone will yield valuable information on the metabolic pathways involved in tumor development and progression. This could generate novel prognostic strategies based on stromal phenotype, and facilitate the development of anti-cancer agents designed to un-couple the relationship between cancer cells and their stromal counterparts.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Colorectal CancerTumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.Imaging Mass SpectrometryBrazil