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Meeting USP 729 globule size distribution in lipid injectable emulsions

Entegris
3 Jul 2022

In this application note, discover USP 729 compliant methods for measuring the critical size characteristics of lipid injectable emulsions including the mean droplet size and the large diameter tail >5 μm. Learn how the Nicomp® DLS system from Entegris, can be used to measure the mean size, and the AccuSizer® single particle optical sizing (SPOS) system , to measure the tails >5 μm.

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Nicomp N3000 Online System

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Dynamic light scattering (DLS) is the most prevalent size analysis technique for nanoparticles. Although the vast majority of DLS size measurements are performed in the laboratory, the nanotechnology revolution has created higher demand for online DLS systems and the Nicomp® Online is a proven industrial solution. Our Nicomp online system allows users to monitor a manufacturing process to ensure a high quality product without waste.

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AccuSizer® SPOS Systems

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A comprehensive portfolio of high accuracy and resolution liquid particle counters that determine particle size and concentation of suspensions

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Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LipidsLipids are a diverse group of organic compounds that are insoluble in water, including fats, oils, and hormones. They are critical for cellular structure and energy storage. Explore lipid analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.USP Method

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Meeting USP 729 globule size distribution in lipid injectable emulsions