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Measuring genetics, 5-mC and 5-hmC at single-base resolution

biomodal
14 Mar 2025

Explore he duet multiomics solution evoC, an innovative sequencing technology that simultaneously resolves the four genetic bases and distinguishes between cytosine modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) (six-base calling). By integrating genetic and epigenetic data at high accuracy, evoC enables deeper insights into gene expression, chromatin accessibility, and enhancer states. Using mouse embryonic stem cells, this method reveals the dynamic interplay between DNA modifications and transcriptional regulation.

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duet multiomics solution evoC

biomodal

Your single solution for multiomics data - Uncover a true 6-base genome for unprecedented insights into current and future biological states. Access all four canonical bases and distinguish 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) from a single 5ng DNA sample, in a single experiment, with high accuracy.

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Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingEpigeneticsEpigenetics refers to heritable changes in gene expression. These changes are not caused by alterations to the DNA sequence. Three of the main systems responsible for the initiation of epigenetic change are DNA methylation, histone modification and non-coding RNA-associated gene silencing.Gene ExpressionChromatin

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Measuring genetics, 5-mC and 5-hmC at single-base resolution