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Measurement of the Tg' in Formulations
18 Jun 2012In designed formulations for lyophilized drugs, it is important to know the collapse temperature of the cake. The collapse temperature is often associated with the Tg’ of the frozen material and measuring this transition is the best way to approximate it. In addition, it is useful to know the amount of non-frozen water, which can be estimated as the enthalpy of melting (ΔH). Both of these necessary values are shown to be obtained with PerkinElmer’s Diamond DSC.
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Thermal Analysis EquipmentThermal analysis equipment is used for measuring heat flow, weight loss, dimension changes or thermomechanical properties and is important for analyzing a material’s performance and stability. Thermal analysis equipment includes differential scanning calorimeters (DSC), thermogravimetric analyzers (TGA), thermomechanical analyzers (TMA), dilatometers, thermometers, vapor sorption analyzers, boiling and melting point apparatus. Thermal analyzers can reveal properties such as melting, crystallization and glass transitions or other processes such as oxidation, decomposition, volatilization, as well as coefficients of thermal expansion and modulus. Find the best thermal analysis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Lyophilized DrugsCollapse Temperature