ResourceLife Sciences
Measurement of plasma CGRP levels in pediatric migraine patients
22 Nov 2019Calcitonin gene-related peptide (CGRP) has been shown to be a biomarker of migraine in adults. CGRP causes dilatation of both peripheral and cerebral blood vessels. Baseline plasma CGRP levels are significantly higher in migraine adult patients than in healthy controls. Additionally, during a migraine attack, the plasma CGRP levels of both adult and pediatric patients increase and strongly correlate with headache intensity. In this study, the scientists explore whether CGRP could be a biomarker helping stratification of migrainous children, by studying the relation between plasma CGRP levels and the responses to anti-migraine therapies.
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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.