ResourceLife Sciences
Maximize success in biotherapeutic antibody development
Discover the key strategies and technologies for successful lead optimization in translational medicine, empowering your biotherapeutic antibody development with robust data and de-risking the path to clinical advancement
24 Jul 2023The demand for novel antibody formats is rising due to their increased use in disease treatment, targeting previously difficult-to-treat areas. Analytical technologies like Biacore™ SPR systems by Cytiva play a significant role in guiding decision-making throughout the development process, from candidate selection to clinical lead. This application note delves into the journey of creating a suitable clinical lead molecule and evaluating the downstream potential of new therapeutics through candidate optimization.
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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.Antibody ProductionAntibody production is essential for a wide range of applications in biochemistry and immunology. Ensuring high-quality monoclonal and polyclonal antibodies are produced is key. Explore antibody production tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.