ResourceSpectroscopy
Matrix-free Small Molecule Analyses Using REDIchip™ on a MALDI Platform
Matrix-free Small Molecule Analyses Using REDIchip™ on a MALDI Platform
13 Sept 2015Standard MALDI techniques are not ideal for small molecule analysis and detection in the lower spectral mass region (m/z < 1000). MS signals for small molecules are often masked or suppressed due to matrix interference. REDIchips (Resonance-Enhanced Desorption Ionization) are sample target plates with nanopost array (NAPA) surfaces for matrix-free laser desorption ionization of small molecules. This application note demonstrates how REDIchips eliminate the need for matrix application on your samples, enabling effective detection of small molecules and mixtures on your MALDI platform.
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MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.