MarqMetrix Process Raman Analyzer real-time monitoring

Crystallization is crucial for ensuring product quality in pharmaceutical manufacturing, affecting particle size, purity, and yield of active pharmaceutical ingredients (APIs). Poor control of the crystallization process can lead to inefficiencies in downstream processes like filtration and drying. Thermo Fisher Scientific highlights the use of the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer as an in-line process analytical technology (PAT) tool for monitoring API crystallization. By combining this analyzer with chemometric analysis, including principal component analysis (PCA), the tool effectively tracks crystallization kinetics and determines the exact completion time. This real-time monitoring ensures better process control and optimization, leading to the production of high-quality crystalline materials and improved overall product quality.