ResourceLife Sciences
Long-Term 3D Human Liver Microtissue Co-Cultures: Characterization and Implication for Drug-Induced Hepatotoxicity Studies
5 Oct 2014Drug-induced liver injury remains the main cause of liver failure and post-market drug withdrawals. In this poster long-term three-dimensional co-cultured human liver microtissues were characterized to assess their suitability for use in drug-induced hepatotoxicity studies.
Related products
Request Quote for All Products
3D InSight™ Human Liver Microtissues
InSpheroDiscover the 3D InSight™ Human Liver Microtissues: the gold standard for Hepatotoxic screening. Pharma-validated co-culture models offer 2x higher DILI prediction sensitivity than 2D hepatocytes. Features pooled PHH from male/female donors co-cultured with Kupffer cells and LECs, 28-day viability, in 96-well format. Includes 50mL 3D InSight™ Liver Maintenance Medium. Check the bi-weekly production schedule online.
Links
Tags
Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Compound AnalysisCompound analysis is used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds have the desired effect, such as interaction with a target protein, during high throughput screening.MicrotissueDrug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.