Lipid nanoparticle and liposome characterization with FFF-MALS-DLS

Lipid nanoparticles (LNPs) and liposomes are variations of lipid-based drug carriers differing in their internal structure. In liposomes, a phospholipid membrane encloses an aqueous inner cavity – a synthetic analog to natural cell walls. LNPs include nano-emulsions, micelles and solid lipid nanoparticles (SLN). Liposomes and LNPs serve as versatile drug delivery systems, offering control over composition, structure, and morphology, where these properties can be tailored to each specific pharmaceutical application. In this whitepaper, Waters | Wyatt Technology discuss the crucial need for comprehensive particle characterization for efficient pharmaceutical product development and regulatory approval. Knowledge of internal structure, mode of drug incorporation, drug loading capacity and drug release kinetics is also of vital importance for the development of a successful drug delivery.