ResourceGeneral Lab
Large-Scale Freezing of Biopharmaceutical Drug Product
13 Nov 2014This application note examines how well the Sartorius Stedim Biotech’ CryoWedge™ models freezing in a large-scale freeze-thaw vessel, or CryoVessel™. A glycine- sucrosephosphate formulation was selected as a representative solution for the freeze-thaw studies. Samples were draw- from the center of the CryoWedge and from the corresponding center of the wedge in the CryoVessel during the freezing process. Samples were subjected to conductivity and pH assays to examine the distribution of solutes.
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Refrigerators Freezers and CryogenicsRefrigerators, Freezers & Cryogenics can be used for preservation or experimental purposes. Types of freezers include deep freeze, -80C°C, ultra-low temperature, explosion proof, cryogenic and controlled rate freezers. Freezing is also used in freeze-drying equipment for dehydration processes. Feature to consider in freezers include temperature control and recorders, failure alarms and self-closing mechanisms.Cryogenic