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Kitted universal MAM: Automatable sample processing for all stages of biological drugs
18 Nov 2021Multiple attribute monitoring (MAM) is an LC-MS based technique designed to simultaneously and directly monitor critical quality attributes (CQAs) of biologics including impurities, PTMs, and sequence. In this poster, Tecan presents an automated solution for the MAM workflow that successfully allows for removal of contaminants through a streamlined workflow usable at all stages from bioreactor to final product.
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Resolvex® A200 Automated ppSPE Workstation
TecanThe Resolvex A200 provides fully automated ppSPE in 1 ml columns and 96-well plates. It uses proven and reliable syringe pump technology to precisely and accurately deliver up to 11 protocol solvents.
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.Process MonitoringSample ProcessingSample processing is required to prepare samples prior to analysis. Technologies used for sample processing include homogenizers, grinders, mills and mixers.