Is your AAV payload impacting stability? Find out with Aura GT

14 Oct 2024

Adeno-associated viruses (AAVs) have transformed gene therapies by enabling the targeted delivery of therapeutic genetic payloads. Aura GT™ from Halo Labs provides a low-volume, high-throughput, and sensitive methodology for comprehensive AAV formulation development. It helps to monitor nucleic acid leakage that can occur under common storage conditions and enables characterization of subvisible particles to improve sample stability.

Aura

Halo Labs

Aura® is the particle and aggregate detection system that combines Backgrounded Membrane Imaging which images 100% of your sample to give you count, size, and morphological information, with up to 2 channels of Fluorescence Membrane Microscopy. Identify if particles are protein or not with the first FMM channel and determine if your sample contains lipids, hydrophobic entities, or other aggregates of your choice with a second.

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Aura CL

Halo Labs

Aura® CL systems couples Fluorescent Membrane Microscopy and Backgrounded Membrane Imaging to help you understand what’s in your cell therapy. It detects, counts, sizes, and IDs cellular aggregates and subvisible particles and ID’s cellular from other particles without any machine learning so you can maximize the purity, safety, and efficacy of your therapeutic.

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Lead OptimizationLead optimization is a phase in the drug discovery process. A lead is a compound that has demonstrated desired biological effects on a target. Optimization involves making chemical modifications to the structure in order to generate analogues of the original compound, which have higher potency and safety profiles.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Viral VectorsDNA AmplificationDNA Amplification is a technique used to amplify a single or multiple copies of DNA or mRNA by orders of magnitude. The most common method employed is PCR, but other options exist that eliminate the need for thermocycling.