ResourceLife Sciences
iPSC-derived motor neurons and microglia from ALS background display disease phenotype
30 Oct 2023Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by the degeneration of motor neurons, and ultimately results in death. In this whitepaper from Sartorius, explore how fibroblasts taken from a healthy individual and an ALS patient carrying a C9orf72 hexanucleotide expansion were reprogrammed to induced pluripotent stem cells, and then differentiated to motor neurons and microglia alongside controls. Results have displayed that this can be used as a robust model for C9orf72 ALS research and drug discovery.
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Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Ipsc