Investigating the effects of respiratory syncytial virus infection on host cell mitochondrial function

15 Mar 2023

Pathogenic viruses have different strategies to ensure ideal environments for their replication and spread, and have evolved to alter numerous host cell pathways. A greater understanding of these metabolic alterations required for viral replication may lead to innovative therapeutic tactics through targeted modification of specific mitochondrial functions or pathways. In this application note, learn about how the Agilent Seahorse XF technology delivers a real-time view of the fundamental processes of energy metabolism in live cells. Understand how this capability enables convenient interrogation of the metabolic implications of pathogen infection on host cells, including those specific to mitochondrial function, offering new insights on key host-pathogen interactions.

Seahorse XF Pro Analyzer

Agilent Technologies

Measure mitochondrial respiration, glycolysis, and ATP production rates in live cells in a 96-well forma t, providing a system-level view of cellular energy metabolism and mitochondrial health. It combines enhanced sensitivity and data consistency with intuitive software and advanced data analytics, enabling users to streamline assay workflow from start to finish and generate and interpret metabolic data easily. 

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