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Introducing Precellys: A tool for nano-milling poorly water-soluble API

Bertin Technologies
5 Jun 2023

In this application note, Bertin Technologies validates the use of Precellys® 24 with Cryolys for nano sizing of poorly water-soluble drugs using different milling protocols. The study was performed using different parameters such as bead diameter, bead concentration, and material. The study showed that the Precellys with Cryolys represents a new technology for drug nano-milling that can be utilized in early discovery and preclinical research.

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Precellys® 24 Touch

Bertin Technologies

Precellys ® 24 Touch is the ideal lab homogenizer to prepare any kind of biological sample, from the softest to the hardest. It can treat up to 24 samples at a time and has been validated on more than 1,500 different samples. The intuitive touchscreen interface of Precellys ® 24 Touch makes it really easy to use. Thanks to its exclusive vacuum-based tube locking system and its specific design, Precellys ® 24 Touch is compliant with the harshest safety requirements, such as BSL3.

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Mills, Sieves and PressesMills, sieves and presses are used to break and sort solid materials into smaller particle sizes for further processing such as pellet pressing or analysis. Milling equipment includes grinders, ball mills, cutting mills, jaw crushers, knife mills, beater and planetary mills. Sorting of smaller particulates can be achieved with test sieves and sieve shakers. Final powders can be pressed with hydraulic presses. Milling and pressing solid samples is an important preparation step in X-ray fluorescence spectroscopy (XRF) and diffraction (XRD). Find the best mills, sieves and presses in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MillingMilling is the process of grinding, crushing, or cutting materials into smaller parts. In scientific research, it plays a crucial role in sample preparation for analysis in areas such as food, pharmaceuticals, and materials science. Explore milling equipment in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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Introducing Precellys: A tool for nano-milling poorly water-soluble API