In Vivo Imaging of a Cy5.5 Labeled Amyloid-β, an Alzheimer's Disease Associated Protein

7 Mar 2014

Alzheimer's disease pathogenesis is widely believed to be driven by the accumulation of amyloid-β peptide (Aβ). This application note describes a method for imaging the dynamics of Aβ trafficking in vivo with injected Cy5.5-labeled Aβ, using the iBox® Explorer™2 Imaging Microscope.

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Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Fluorescence MicroscopyFluorescence microscopy has become an essential tool in biology, as well as in materials science. The application of many fluorochromes has made it possible to identify cells and sub-microscopic cellular components with a high degree of specificity. Using multiple fluorescence labels, different probes can simultaneously identify several target molecules.Alzheimers ResearchAlzheimer�s disease is a neurodegenerative condition characterized by progressive memory loss and cognitive decline. Research focuses on understanding the molecular and cellular mechanisms of the disease, as well as developing effective treatments and diagnostic tools. Browse our peer-reviewed product directory to find the best Alzheimer�s research products, compare options, check reviews, and get pricing directly from manufacturers.
In Vivo Imaging of a Cy5.5 Labeled Amyloid-β, an Alzheimer's Disease Associated Protein