In-line monitoring of liposome size by RT-MALS

In liposome and lipid nanoparticle (LNP) drug-delivery applications, particle size is a critical quality attribute (CQA) that impacts bioaccessibility, retention time and biodistribution. Current on-line and off-line control methods do not sample the entire batch, and only provide average sizes, potentially hiding pockets of out-of-spec material. In this application note, Wyatt Technology demonstrates how real-time multi-angle light scattering (RT-MALS) can ensure batch consistency through in-line monitoring.