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Impurity Testing of Fixed-Dose Combination Drugs Using the Agilent 1290 Infinity II HDR-DAD Impurity Analyzer Solution
6 Aug 2020This Application Note demonstrates that one injection is adequate to reliably quantify low-dose, high-dose, and trace compounds of a fi xed-dose combination drug using the Agilent 1290 Infi nity II HDR-DAD Impurity Analyzer Solution.
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Agilent 1290 Infinity III HDR-DAD Impurity Analyzer System
Agilent TechnologiesThe 1290 Infinity III HDR-DAD Impurity Analyzer System has a 30 times higher dynamic range, 30 times higher UV sensitivity, plus UHPLC resolution and speed. Detect and quantify every component in your sample in a single run with superior area precision for low-level impurities.
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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.