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Identification of insulin oligomeric states using SEC-MALS
28 Jan 2020To ensure patient safety, it is important to understand the molecular properties of the insulin being taken by patients, for example, which oligomeric species are present. This application note from Wyatt Technology discusses how the combination of column chromatography and multi-angle light scattering (MALS) can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.
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DAWN™
Waters | Wyatt TechnologyThe DAWN is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution, offering the highest sensitivity and widest range of molecular weight, size, concentration and optional features.
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