Identification of impurities in an expired standard drug mixture by using multiple ionization methods and msFineAnalysis

Gas chromatography combined with high-resolution time-of-flight mass spectrometry (GC-HRTOFMS) is a powerful tool for the analysis of complex mixtures. The AccuTOF GC-Alpha (JMS-T2000GC) mass spectrometer is fast, accurate, and sensitive with a high mass resolving power and high mass accuracy. In this application note, GC-MS analysis of a 12-year-old standard drug mixture was carried out with the AccuTOF GC-Alpha (JEOL JMS-T2000GC) mass spectrometer using the combination electron ionization/ photoionization (EI/PI) ion source and the chemical ionization (CI) ion source.