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Identification of GLP-1 analog oligomeric states using SEC-MALS
3 Feb 2025Explore the use of size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) to characterize glucagon-like peptide-1 analogs (GLP-1a) like liraglutide and semaglutide. By analyzing monomers, oligomers, and aggregates under native and denaturing conditions, SEC-MALS ensures proper formulation, reducing undesirable high-order structures to enhance the safety and efficacy of GLP-1a therapeutics.
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Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.