ResourceLife Sciences
Human Liver Microtissues as a Novel System to Predict Inflammation-Mediated Toxicity
20 Feb 2015The GravityPlus system allows the production of regular-sized human liver microtissues with a morphology and architecture close to native liver tissue, in particular when co-cultured with non-parenchymal liver cells. Idiosyncratic toxicity is a severe problem for the pharmaceutical industry. Drugs such as Trovafloxacin were withdrawn due to idiosyncratic hepatotoxicity which was not detected in pre-clinical animal studies. This poster shows, for the first time, an immune-competent in vitro model to study inflammation-mediated toxicity.
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicrotissueInflammationHepatotoxicity