Human biomonitoring: Attogram level sensitivity and consequences for analytical standards purity

24 Nov 2025

The objectives of human exposure assessment to environmental chemicals are to quantify the magnitude, duration, frequency and routes of exposure, and to characterize and enumerate the exposed population. Biomonitoring is an assessment of the internal dose by measuring a toxicant (or its metabolite or protein adduct) in human blood, urine, milk, saliva, adipose tissue, or other tissues. In this application note, Cambridge Isotope Laboratories describes a biomonitoring approach providing a direct measure of exposure that integrates exposures from multiple pathways and sources.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Environmental ContaminationContaminants in the environment are harmful chemicals that are present in the air, land and water. These include pesticides, pharmaceuticals, persistent organic pollutants (POPs) and many more.Environmental AnalysisEnvironmental analysis describes a variety of tests that determine the effect of chemicals, processes and particulates such as persistent organic pollutants (POPs) have on the environment.
Human biomonitoring: Attogram level sensitivity and consequences for analytical standards purity