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HPLC Analysis of Drug-to-Antibody Ratio Using YMC’s BioPro HIC BF
26 Jun 2019In this application note, YMC outlines how the unmodified cysteine-conjugated antibody-drug conjugate (ADC) mimic, and its drug-to-antibody ratio (DAR), is well resolved on the BioPro BF column.
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BioPro HIC Columns from YMC: High Throughput and Loadability
YMC EuropeBioPro HIC columns based on non-porous hydrophilic polymer beads and functionalised with butyl chains are optimised for the analysis of antibodies, antibody-drug conjugates (ADCs) and other proteins.
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Ion ChromatographyIon chromatography, also known as ion exchange chromatography, is a high-performance liquid chromatographic technique used for the separation and identification of ions or polar molecules in a sample, including proteins, nucleotides and amino acids. Equipment includes ion exchange columns, ion exclusion columns, ion chromatography systems, pumps, and detectors. Find the best ion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Antibody Drug Conjugates