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How to enhance bioprocess control with ZipChip CE-MS for direct mAb quality analysis

908 Devices
15 Jan 2025

As biopharmaceuticals evolve, achieving precise control over monoclonal antibody (mAb) quality is critical for therapeutic efficacy and regulatory compliance. Explore how using ZipChip Capillary Electrophoresis-Mass Spectrometry (CE-MS) for direct spent media analysis enables the efficient monitoring of mAb quality attributes during bioprocessing. By comparing continuous and bolus glucose feeding strategies in CHO cell cultures, learn how ZipChip CE-MS provides insights into molecular weight, charge, and glycoform heterogeneity, with minimal sample preparation. Enhanced product quality, characterized by reduced glycation and improved glycoform profiles, underscores the potential of this method for advancing bioprocess control.

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ZipChip™

Repligen Corp

ZipChip enables seamless CE/ESI-MS workflow and provides fast CE separation, nano-spray level sensitivity to obtain high-resolution separation and mass spec data from characterization of intact proteins, antibody drug conjugates (ADCs), antibody subunits, peptides, and nucleic acids. 

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Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.

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How to enhance bioprocess control with ZipChip CE-MS for direct mAb quality analysis