Hot-Melt Extrusion Compendium
4 Nov 2024Hot-melt extrusion (HME) can help achieve the needed high efficacy, overcome bioavailability issues of an active pharmaceutical ingredient (API), and tailor release profiles. HME is a straightforward technique in which solid dispersion of drug particles or molecules in a polymer matrix is achieved. Depending on the processing conditions and the chemical and physical properties of polymers and APIs, different types of dispersions are possible. Explore the versatility of HME, discover what happens when materials are heated, and learn how to design a solvent-free HME process and how to produce different dosage forms.
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Thermo Scientific™ Pharma11 Twin-screw Extruder
Thermo Fisher ScientificThe Thermo Scientific Pharma 11 is a unique, flexible twin screw extruder for hot melt extrusion and twin screw granulation.
Thermo Scientific™ Pharma16 Twin-Screw Extruder
Thermo Fisher ScientificRapidly develop pharmaceutical formulations and adopt continuous processing methods using the Pharma 16 Twin-Screw Extruder. It can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific extruders using minimal amounts of expensive APIs and excipients.