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Homogenization and Extraction of Fluorescent Chemical Compounds from Mouse Bone Tissue
14 Jun 2017Bone-targeted drug delivery can be achieved through covalent binding of drugs to hydroxybisphosphonates (HBP), a class of molecule known for high affinity to bone. Extraction of HBP-conjugated chemical from bone is challenging and require efficient tissue homogenization. This application note demonstrates how the Precellys® Evolution system was tested for bone homogenization and compared with a cryogenic grinder.
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Precellys® Evolution - Tissue Homogenizer
Bertin TechnologiesThis product has been discontinued. See the newer version of this product linked below.
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Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Homogenizers and BlendersHomogenizers and blenders are used to homogenize various types of material, including tissue, cells, plants, food, soil, biological and chemical samples for subsequent analysis. Lab equipment for sample homogenization includes handheld and benchtop homogenizers, bead mill, ultrasonic and multiple sample homogenizers, high shear homogenizers and blenders. Homogenizer bead and probe multipacks are available to avoid cross contamination of samples, as well as cooling systems for homogenizing temperature-sensitive samples. Homogenizers are often used in the first step of extraction of DNA, RNA and proteins from tissue and cell samples. Find the best homogenizers and blenders in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.