ResourceLife Sciences
High-Throughput Genotoxicity Assays
5 Feb 2019Preclinical safety assessments often include the in vitro micronucleus assay in order to evaluate chemicals' potential to cause DNA damage. This particular assay provides information on chromosomal damage in cultured cells by detecting the formation of small membrane-bound DNA fragments (micronuclei) in the cytoplasm of interphase cells. Traditionally, the in vitro micronucleus assay requires a microscopic analysis of the treated cells which precludes its use as a high-throughput screening tool.
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MACSQuant® Analyzer 10 Flow Cytometer
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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.GenotoxicityCell Based AssaysCell-based assays use living cells to measure biological responses to various treatments or stimuli. They are essential for drug discovery, toxicology testing, and understanding cellular mechanisms. These assays are used to assess cell viability, proliferation, gene expression, and other cellular activities. Browse our peer-reviewed product directory to find the best cell-based assay tools and reagents, compare products, read customer reviews, and get pricing directly from manufacturers.DNA Damage