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High sensitivity analysis of potential mutagenic boronic acids using Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer with an ACQUITY premier system

22 Jun 2022

Boronic acids and their esters are common reagents used in the synthesis of organic compounds. Several boronic acids have been identified as potential mutagens and should be controlled at low levels using sensitive methods. In this application note, Waters describes an Ultra Performance Liquid Chromatography (UPLC) method with tandem quadrupole mass spectrometer for high sensitivity quantification of seven boronic acids with mutagenic potential.

Xevo TQ MS

Waters

Waters Xevo™ TQ MS provides the ultimate in quantitative capabilities for your most demanding applications and your most complex sample matrices. It is a highly advanced tandem quadrupole mass spectrometer designed to enable uncomplicated access to superior HPLC and UPLC®/MS/MS performance, delivering the highest levels of sensitivity, selectivity, robustness, speed, and accuracy. Waters Xevo TQ MS is equipped with unique collision cell technology (ScanWave™) to provide new enhanced spectral LC/MS/MS data acquisition capabilities. Unlike conventional tandem quadrupole mass spectrometers, the Xevo TQ MS is designed not only to provide the very best quantitative data, but also to provide you with superior spectral MS/MS information. Xevo TQ MS offers you much more versatility in a single instrument platform that is adaptable to a variety of different UPLC/MS/MS applications both quantitative and qualitative: bioanalysis, ADME screening, food safety, environmental monitoring, forensic, and more. Features: Automated system set up and system checks for simple access Automated instrument optimization and quantitative method development tools for ease-of-use The latest innovations in high efficiency, robust, easy-to-use ZSpray™ atmospheric pressure ion source technology Versatile range of ionization options, including multi-mode ionization capability in a single run Unique, innovative T-Wave™ and ScanWave enabled collision cell technology Footprint that sits easily on your laboratory benchtop Dedicated application managers for your specialized analytical requirements

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Triple Quadrupole Ms
High sensitivity analysis of potential mutagenic boronic acids using Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer with an ACQUITY premier system