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Guide to implementing cannabinoid potency testing: Robust analytical methods for cannabinoid content in consumer products

4 Jan 2023

Reliable and effective methods for cannabinoid potency testing in consumer products are needed to meet established or rapidly evolving regulatory requirements that differ widely across countries and states. In this eBook, we look at the latest chromatographic methods and technologies that enable the effective determination of cannabinoid content in chemically complex products, ranging from chocolate to hard candies and beverages and how this helps to ensure product safety and adequate labeling.

Download the eBook to learn how to overcome sample preparation and the technical challenges of cannabinoid content testing, including the analysis of tetrahydrocannabinol (THC) and cannabidiol (CBD) using LC/UV instruments from Agilent Technologies, and discover workflows that produce accurate, high-throughput results with reduced column downtime and increased lab productivity.

Find detailed methods and resources, including:

  • The quantification of THC and CBD in beverages
  • The quantification of THC and CBD in gummies and hard candies
  • The quantification of THC and CBD in chocolate
  • A guide to potency testing columns and supplies

Agilent 1260 Infinity II LC System

Agilent Technologies

The 1260 Infinity II LC System is a robust HPLC that offers the widest choice of modules for analytical HPLC and entry-level UHPLC, delivering the performance, reliability, and robustness you need for highest confidence in your daily results.

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Agilent 1220 Infinity II LC System

Agilent Technologies

The 1220 Infinity II LC is an integrated system for routine HPLC analysis in analytical and QA/QC labs. Based on the proven technology of the InfinityLab LC Series, the system's high quality and performance help you achieve maximum return on investment and lowest cost of ownership from day one.

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Captiva EMR-Lipid

Agilent Technologies

Captiva EMR-Lipid provides highly selective, efficient lipid/matrix removal without analyte loss. The novel EMR-Lipid technology removes lipids based on size exclusion and hydrophobic interaction. Effective lipid removal ensures minimal ion suppression of target analytes, significantly improving method reliability and ruggedness.  

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.UV-Visible SpectroscopyUltraviolet-visible (UV-Vis) spectrophotometers are used to measure the interaction of UV and visible light with a sample, including transmission, reflectance & absorbance. The two major instrument classes are single-beam or double-beam spectrophotometers. More specialized equipment includes colorimeters, spectroradiometers and refractometers. Portable and microvolume spectrophotometers are also available. For the modular spectroscopy lab, explore a range of light sources for combination with a spectrograph/spectrometer and optics. Find the best UV-Vis spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
Guide to implementing cannabinoid potency testing: Robust analytical methods for cannabinoid content in consumer products