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Gold and Silver Coated Nano Particles: Characterizing Coating Thickness for Nano-scale Drug Delivery

28 Jul 2013

This application note describes how, using the technique of Differential Centrifugal Sedimentation (DCS), peaks in particle size distributions for both the coated and uncoated particles can easily be separated and resolved; making this technique an ideal characterization tool, enabling coating thickness to be measured and the coating process monitored.

CPS Disc Centrifuge UHR Nanoparticle Size Analyser

Analytik Ltd

CPS DC24000 UHR nanoparticle size analyser is an effective analytical tool for ultra high resolution, high accuracy measurement of particle size distribution. Highly poly-dispersed particles can be measured in the size range of ~2.0nm to ~75 microns, at 2 to 10 times better resolution than any other particle sizing instrument, regardless of measurement technique.Utilising Differential Centrifugal Sedimentation (DCS), the CPS Disc Centrifuge UHR offers the unique ability to resolve very close multimodal particle distributions and to distinguish extremely small shifts in particle size. Rather than using a predictive algorithm, the instrument physically separates the nanoparticles and then measures them as they pass a light source detector - providing full characterisation in real time.CPS Disc Centrifuge UHR Nanoparticle Size Analyser Features: Ultra high resolution with clean separation of narrow peaks that differ in size by as little as 2% Able to detect and measure very small and subtle changes / differences in particle size Able to measure / monitor nanoparticle coating thickness Very high sensitivity; minimum detection limit below 10-8 gram active sample for narrow peaks Highly reproducible results Dynamic range capability >1000 for measurement of broad and multimodal distributions Measurement of particles of virtually any density Wide range of data presentation options, including multiple distribution overlays

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Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DosageDosage is the size or frequency of the administration of a drug. Determination of the dosage of a drug is critical in pharmaceutical development to ensure the optimum balance between efficacy and toxicity.
Gold and Silver Coated Nano Particles: Characterizing Coating Thickness for Nano-scale Drug Delivery