ResourceLife Sciences
Functional analysis of PHLDA3, a target gene for the tumor suppressor gene p53
10 Apr 2023In this application note, discover more about the use of Beckman Coulter Life Sciences AMPure XP DNA clean-up process in the research of targeting p53. Beckman interviews Dr. Reiko Ohki, Head of Fundamental Oncology, National Center, Tokyo, who works on p53, its downstream factors and its role in tumorigenesis. She discussed the importance of the DNA clean-up process in the analysis of mutations in PHLDA3 genes in cancer tissues she is analyzing.
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Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.