From lenses to semi-permeable capsules: How scientists keep getting closer to life itself

19 Aug 2025

Single-cell biology has moved from “seeing cells” to explaining how information becomes function. That shift exposed a practical bottleneck: we need platforms that keep single-cell resolution and let us run multi-step workflows at scale. Atrandi Biosciences’ patented Semi-Permeable Capsule (SPC) technology answers that need. SPCs isolate individual cells inside permeable hydrogel shells, so you can swap buffers, stage incompatible reactions, culture or lyse, then barcode and sequence, across tens of thousands of cells in parallel. In this paper, we trace the road to single-cell thinking, outline where current compartments fall short, and show how SPCs open up robust genomics and assay development, especially for eukaryotic systems.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Single Cell GenomicsSingle Cell AnalysisSingle-cell analysis involves studying individual cells to gain insights into their behavior, gene expression, and function. This approach is valuable in cancer research, stem cell biology, and immunology. Explore single-cell analysis products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.MicrofluidicsMicrofluidics is the science of manipulating small volumes of fluids in micro-sized channels. It is widely used in diagnostics, drug development, and lab-on-a-chip technologies. Microfluidic devices can enable rapid, cost-effective, and high-throughput analysis of biological samples. Browse our peer-reviewed product directory to find the best microfluidic devices, compare products, check reviews, and get pricing directly from manufacturers.
From lenses to semi-permeable capsules: How scientists keep getting closer to life itself