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Freeze drying: Illustrated toolkit for general users

15 Sept 2019

Freeze-drying is not a straightforward process and it requires a good balance of several factors. In this application note, BUCHI explores freeze-drying hardware, discusses the most important parameters and steps in sample preparation, outlines the freeze-drying process itself, and finally explains how to perform freeze drying when solvents other than water are used, either pure or diluted.

Lyovapor™ L-300

BUCHI

With Infinite-Technology™ the Lyovapor™ L-300 is the first continuous sublimation system available on the market. The instrument contains two alternating condensers that operate at -105 °C and undergo automatic hygenic cleansing. In addition, Infinite-Control™ allows entire process control of all relevant parameters via mobile devices or a stationary computer.

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Evaporators and Freeze DryersCentrifugal evaporation is used for solvent removal from a sample. This is a useful technique for sample concentration or sample drying. Many centrifugal evaporators are modular with a central vacuum pump for generating low pressure. Useful features of evaporators or vacuum ovens include minimal solvent bumping, solvent resistance, computer control, temperature regulation and benchtop design.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.Freeze Drying
Freeze drying: Illustrated toolkit for general users