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Freeze-drying illustrated laboratory guide

18 Dec 2025

Freeze-drying is not a quick process, and cycles can take a few days and up to a week to complete. It requires a good balance of several factors, and a good understanding of freeze-drying concepts is crucial to achieving a successful process.

In this guide, Buchi provides technical notes and answers to frequently asked questions to support successful freeze-drying for a wide range of applications. This includes how to choose the right hardware, important sample preparation steps, and how to perform freeze-drying when using solvents other than water.

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Evaporators and Freeze DryersCentrifugal evaporation is used for solvent removal from a sample. This is a useful technique for sample concentration or sample drying. Many centrifugal evaporators are modular with a central vacuum pump for generating low pressure. Useful features of evaporators or vacuum ovens include minimal solvent bumping, solvent resistance, computer control, temperature regulation and benchtop design.Freeze Drying