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Formation of Spheroids and Suppression of Adhesion by Adherent Growing Cells in inertGrade™ Microplates

BRANDTECH® Scientific, Inc.
11 Nov 2016

Suppression of the integrin mediated cell adhesion is vital in many experimental procedures, such as the production of embryonic bodies, self-assembled 3D cultures, and tumor spheroids. This application note describes a study in which BRANDplates® interGrade™ microplates where used to successfully suppress adhesion of a variety of adherent growing cell lines. The study also compares interGrade™ to competitor cell-repellent surfaces and found that when using interGrade™, larger numbers of smaller aggregates form and are uniformly distributed over the entire well surface when using.

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BRANDplates Cell Culture Microplates - inertGrade™

BRANDTECH® Scientific, Inc.

BRANDplates® inertGrade™ 96-well plates are especially suited for cell culture applications when adhesion is not desired. These plates are specifically designed for the cultivation of suspension, tumor, and stem cells, as well as other spheroid or 3-dimensional tissue culture models. They feature a surface that reduces cell adhesion and protein absorption to minimize enzyme and cellular activation. All BRANDplates® inertGrade™ microplates are sterile according to Ph. Eur. and USP 29, SAL10-6, and are alphanumerically coded with orange embossing for easy plate and well identification. Available clear, white, and black, with U- F- or C-bottom, as well as white or black with transparent bottom, to suit your needs.  

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AggregationEmbryonic Stem CellsSpheroidsSpheroids are clusters of cells that have been grown in 3D culture to be used as <i>in vitro</i> model systems. These 3D microtissues can be used for toxicology testing, DMPK studies and many other applications involving cell analysis.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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Formation of Spheroids and Suppression of Adhesion by Adherent Growing Cells in inertGrade™ Microplates