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Fluoxetine (Prozac)
23 Mar 2022Fluoxetine can have a tendency to tail in some HPLC methods due to its secondary amine group. In this application note, MicroSolv Technology Corporation demonstrates how peak shape with the Cogent Amide Column was found to be highly symmetrical without the aid of ion pairing agents. This allows the method conditions to be adapted to LC-MS if needed.
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Cogent Amide Hydride™
MicroSolv Technology Corp.Cogent Amide Hydride™ HPLC Columns are manufactured with TYPE-C™ silica (silica hydride) and have an ethyl amide functional group bonded to the silica particle with direct, silicone-carbon bonds. The manufacturing of silica makes these columns extremely stable.
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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.